Recent neuroscientific research overturn the long-held belief that no new neurons form in the adult brain and that only nerve cell death can occur. There is evidence that neurogenesis occur in the subgranular zone of the dentate gyrus and the subventricular zone of caudate nucleus in the adult brain. New neurons differentiate from a population of progenitor cells from these neurogenic regions and they are identified by imunofluorescent labelling for bromodeoxyuridine (BrdU), a thymidine analog that labels DNA during the S phase. Researchers have also shown that new neurons are continually being added to the cerebral cortex of adult Rhessus monkeys. We review this research with major implications for neuroscience and we discuss the possible role of neurogenesis in the adult brain.
KEYWORDS: neurogenesis, dentate gyrus, bromodeoxyuridine