The relationship between cognitive functions and disinhibition: Observations of cognitively impaired patients

Written by Naohiko Yamagami, Chiyoko Nagai, Fumiaki Saito, Masahiro Sonoo on 29 September 2023. Posted in Volume XXVII, Nr 2

Authors

Naohiko Yamagami^1,*, Chiyoko Nagai², Fumiaki Saito¹, Masahiro Sonoo¹

¹ Department of Neurology, Teikyo University School of Medicine, Tokyo, Japan
² Department of Speech-Language-Hearing Therapy, Faculty of Health and Medical Science, Teikyo Heisei University, Tokyo, Japan

Abstract

Inhibitory control exhibits a significant correlation with overall cognitive abilities. Past research largely measured disinhibition using experimental protocols, predominantly featuring healthy or youthful participants, or caregiver-supplied information, potentially neglecting an objective assessment of pronounced disinhibition within a naturalistic context. We posit that the observation of prominent disinhibition behaviors across various cognitive assessment tasks provides an objective measurement of innate disinhibition, bypassing the need for participant awareness or concentrated effort toward inhibition. The present study, designed as a secondary analysis of prior research, aims to explore the relationship between cognitive functions and observed disinhibition behavior during cognitive testing in patients exhibiting cognitive impairment symptoms. A retrospective analysis was performed on the records of 224 patients' cognitive tests, including recorded disinhibition behavior, without employing any exclusion criteria. Findings revealed that patients demonstrating at least one instance of disinhibition during testing presented significantly lower overall cognitive functions, excluding long-term memory, than their counterparts without disinhibition. Notably, multiple regression analysis identified comprehension and conceptualization abilities as significant predictors of disinhibition severity. These findings, aligning with earlier research, serve to strengthen the credibility of previous studies on this topic.

Keywords: inhibitory control, disinhibition, cognitive impairment, COGNISTAT

PAGES:229-241

doi:10.24193/cbb.2023.27.11

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