BRAIN ASYMMETRIES RELATED TO LANGUAGE WITH EMPHASIS ON ENTORHINAL CORTEX AND BASAL FOREBRAIN

Written by Goran SIMIC, Mihovil MLADINOV, Milos JUDAS, Patrick R. HOF on 15 December 2006. Posted in Special issue: Brain Asymmetry, Guest Editors: Joseph B. HELLIGE, Joseph E. BOGEN, Volume X, Nr. 2

Abstract:

Anatomical asymmetries of the human brain are important in at least four respects: 1) they can serve as potential indicators of the evolutionary foundations of language, 2) they can be used for comparative analysis of neural specializations for communication in primates, 3) they may provide underlying structural correlates for functional imaging (fMRI, PET) and genetic studies, and finally 4) they can be used for studying disorders which are suspected to result from either disturbed development of cerebral asymmetry or asymmetric damage to the brain. In the first part of this review, we give a general framework of this field through the brief descriptions of the milestone discoveries and major conceptual advances as they emerged throughout the last 150 years. In the second part, we provide a more detailed view on the functional relevance that asymmetries of the entorhinal cortex and basal forebrain may have on the language.

Keywords: brain asymmetry, cerebral lateralization, language